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FZD6 Rabbit pAb

Anti-FZD6 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S214022

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S214022
Product Name:   Anti-FZD6 Rabbit Polyclonal Antibody
Synonyms:   FZ6; FZ-6; HFZ6; NDNC10
UNIPROT ID:   O60353 (Gene Accession – NP_001158087 )
Background:    This gene represents a member of the ‘frizzled’ gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Immunogen:    Synthetic peptide of human FZD6
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 214022(FZD6 Antibody) at a dilution of 1/60(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 214022(Anti-FZD6 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 214022(Anti-FZD6 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D161205(Anti-FZD6 Antibody) at dilution 1/60.
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