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GALR2 Rabbit pAb

Anti-GALR2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222061

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222061
Product Name:   Anti-GALR2 Rabbit Polyclonal Antibody
Synonyms:   GAL2-R; GALNR2; GALR-2
UNIPROT ID:   O43603 (Gene Accession – NP_003848 )
Background:    Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Immunogen:    Synthetic peptide of human GALR2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 222061(GALR2 Antibody) at a dilution of 1/25(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 222061(Anti-GALR2 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 222061(Anti-GALR2 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with synthetic peptide and then with D263963(Anti-GALR2 Antibody) at dilution 1/25.
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