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GFI1 Rabbit pAb

Anti-GFI1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222077

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222077
Product Name:   Anti-GFI1 Rabbit Polyclonal Antibody
Synonyms:   SCN2; GFI-1; GFI1A; ZNF163
UNIPROT ID:   Q99684 (Gene Accession – NP_005254 )
Background:    This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Immunogen:    Synthetic peptide of human GFI1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 222077(GFI1 Antibody) at a dilution of 1/60(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 222077(Anti-GFI1 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 222077(Anti-GFI1 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with synthetic peptide and then with D263984(Anti-GFI1 Antibody) at dilution 1/60.
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