Email: info@neweastbio.com   |  Call: 6109452007

Glucocorticoid Receptor Rabbit mAb

Anti-Glucocorticoid Receptor Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262278

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262278
Product Name:   Anti-Glucocorticoid Receptor Rabbit Monoclonal Antibody
Synonyms:   GR; GCR; GRL; GCCR; GCRST
UNIPROT ID:   P06537
Background:    Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5′ UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.
Immunogen:    Recombinant protein of mouse Glucocorticoid Receptor
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R04-8C8
MW:    Calculated MW: 87 kDa; Observed MW: 94,91 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of Glucocorticoid Receptor(green) in Hela using Glucocorticoid Receptor antibody,and DAPI(blue)

Western blot analysis of Glucocorticoid Receptor in rat skeletal muscle lysates using Glucocorticoid Receptor antibody.

Western blot analysis of Glucocorticoid Receptor in K562, 3T3, Hela lysates using Glucocorticoid Receptor antibody.
          Publications