Email: info@neweastbio.com   |  Call: 6109452007

GPER1 Rabbit pAb

Anti-GPER1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222055

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222055
Product Name:   Anti-GPER1 Rabbit Polyclonal Antibody
Synonyms:   mER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br
UNIPROT ID:   Q99527 (Gene Accession – NP_001496 )
Background:    This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function.
Immunogen:    Synthetic peptide of human GPER1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-50; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer using 222055(GPER1 Antibody) at a dilution of 1/25(Cytoplasm and Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer is first treated with the synthetic peptide and then with 222055(Anti-GPER1 Antibody) at dilution 1/25.
          Publications