NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N262304 | ||
Product Name: Anti-GRP78 BiP Rabbit Monoclonal Antibody | ||
Synonyms: HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP | ||
UNIPROT ID: P11021 | ||
Background: When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) (PubMed 8020977) pointed out that one of these, GRP78 (HSPA5), also referred to as ‘immunoglobulin heavy chain-binding protein’ (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). | ||
Immunogen: A synthetic peptide of human GRP78 BiP | ||
Applications: WB,IHC-P | ||
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Monoclonal | ||
Clone ID: R03-5B3 | ||
MW: Calculated MW: 72 kDa; Observed MW: 78 kDa | ||
Isotype: IgG | ||
Purification: Affinity Purified | ||
Species Reactivity: Human,Rat | ||
Conjugation: Unconjugated | ||
Modification: Unmodified | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: NeuroscienceyyyyyPrion disease | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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