NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261418 |
Product Name: Anti-HDAC2 (2D9) Mouse Monoclonal Antibody |
Synonyms: HDAC2; Histone deacetylase 2; HD2 |
UNIPROT ID: Q92769 |
Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. |
Immunogen: Purified recombinant human HDAC2 protein fragments expressed in E.coli. |
Applications: WB,ICC/IF |
Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 |
Host Species: Mouse |
Clonality: Mouse Monoclonal |
Clone ID: 2D9-F6-G7 |
MW: Calculated MW: 55 kDa; Observed MW: 60 kDa |
Isotype: IgG2b |
Purification: Affinity Purified |
Species Reactivity: Human,Mouse,Rat,Monkey |
Conjugation: Unconjugated |
Modification: Unmodified |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide |
Research Areas: Epigenetics and Nuclear Signaling |
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing |
Western blot analysis of HDAC2 in THP-1, SH-SY5Y, K562, COS7, C6, 3T3 and Hela lysates using HDAC2 antibody. |