NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261008 | ||||
Product Name: Anti-HDAC4 (4A3) Mouse Monoclonal Antibody | ||||
Synonyms: EC 3.5.1.98; HA6116; HD 4; HD4; HDAC 4; HDAC A; HDAC4; HDAC4_HUMAN; HDACA; Histone Deacetylase 4; Histone Deacetylase A; KIAA0288. | ||||
UNIPROT ID: P56524 | ||||
Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. | ||||
Immunogen: Purified recombinant human HDAC4 protein fragments expressed in E.coli | ||||
Applications: WB,IP | ||||
Recommended Dilutions: WB: 1/500-1/1000 IP: 1/20 | ||||
Host Species: Mouse | ||||
Clonality: Mouse Monoclonal | ||||
Clone ID: 4A3-H7-C6 | ||||
MW: Calculated MW: 119 kDa; Observed MW: 140 kDa | ||||
Isotype: IgG2a | ||||
Purification: Affinity Purified | ||||
Species Reactivity: Human,Mouse,Rat,Monkey | ||||
Conjugation: Unconjugated | ||||
Modification: Unmodified | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
Research Areas: EpigeneticsyyyyyHistone Acetylation | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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