Email: info@neweastbio.com   |  Call: 6109452007

HDAC4 Rabbit pAb

Anti-HDAC4 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221360

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221360
Product Name:   Anti-HDAC4 Rabbit Polyclonal Antibody
Synonyms:   HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID
UNIPROT ID:   P56524 (Gene Accession – NP_006028 )
Background:    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Immunogen:    Synthetic peptide of human HDAC4
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cardiovascular, Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 221360(HDAC4 Antibody) at a dilution of 1/40(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 221360(Anti-HDAC4 Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 221360(Anti-HDAC4 Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with synthetic peptide and then with D262917(Anti-HDAC4 Antibody) at dilution 1/40.
          Publications