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HEXIM1 Rabbit pAb

Anti-HEXIM1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225448

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225448
Product Name:   Anti-HEXIM1 Rabbit pAb
Synonyms:   CLP1; EDG1; HIS1; MAQ1
UNIPROT ID:   O94992
Background:    Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Immunogen:    The antiserum was produced against synthesized peptide derived from human HEXIM1. AA range:181-230
Applications:    WB,IHC-F,IHC-P,ICC/IF,ELISA
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 41 kDa; Observed MW: 41 kDa
Isotype:    IgG
Purification:    Affinity Chromatography
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunofluorescence analysis of HEXIM1 in HeLa using HEXIM1 antibody. The picture on the right is blocked using the synthesized peptide.

Western blot analysis of HEXIM1 in rat HEART lysates using HEXIM1 antibody.

Western blot analysis of HEXIM1 in NIH/3T3 lysates using HEXIM1 antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of HEXIM1 in theHeLa lysates using HEXIM1 antibody
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