NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261656 | ||
Product Name: Anti-HMGB1 Rabbit Monoclonal Antibody | ||
Synonyms: HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1 | ||
UNIPROT ID: P09429 | ||
Background: High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFκB family, ATF-2 and c-Jun to activate transcription. | ||
Immunogen: A synthetic peptide of human HMGB1 | ||
Applications: WB,IHC-P | ||
Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Monoclonal | ||
Clone ID: R07-2D8 | ||
MW: Calculated MW: 25 kDa; Observed MW: 25 kDa | ||
Isotype: IgG | ||
Purification: Affinity Purified | ||
Species Reactivity: Human,Mouse,Rat | ||
Conjugation: Unconjugated | ||
Modification: Unmodified | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: Epigenetics and Nuclear Signaling | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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