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HP1 alpha (1E8) Mouse mAb

Anti-HP1 alpha (1E8) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261349

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261349
Product Name:   Anti-HP1 alpha (1E8) Mouse Monoclonal Antibody
Synonyms:   CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
UNIPROT ID:   P45973
Background:    Component of heterochromatin that recognizes and binds histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Immunogen:    Purified recombinant protein expressed in E.coli.
Applications:    WB,IHC-P
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    1E8-5C3-10E1
MW:    Calculated MW: 22 kDa; Observed MW: 22 kDa
Isotype:    IgG1
Purification:    Affinity Purified
Species Reactivity:    Human,Rat,Mouse
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemical analysis of paraffin-embedded Human tonsils using HP1 alpha (1E8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP1 alpha (1E8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human Placenta Tissue using HP1 alpha (1E8) antibody High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of HP1 alpha (1E8) in COS7, Hela lysates using HP1 alpha (1E8) antibody.
          Publications