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HUS1 Rabbit pAb

Anti-HUS1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218860

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218860
Product Name:   Anti-HUS1 Rabbit Polyclonal Antibody
Synonyms:   hHUS1
UNIPROT ID:   O60921 (Gene Accession – BC007013 )
Background:    The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Immunogen:    Fusion protein of human HUS1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 218860(HUS1 Antibody) at a dilution of 1/65(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the fusion protein and then with 218860(Anti-HUS1 Antibody) at dilution 1/65.

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 218860(Anti-HUS1 Antibody) at a dilution of 1/65.

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with fusion protein and then with D225393(Anti-HUS1 Antibody) at dilution 1/65.
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