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IGF1R Rabbit pAb

Anti-IGF1R Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S215206

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S215206
Product Name:   Anti-IGF1R Rabbit Polyclonal Antibody
Synonyms:   IGFR; CD221; IGFIR; JTK13
UNIPROT ID:   P08069 (Gene Accession – NP_000866 )
Background:    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Immunogen:    Synthetic peptide of human IGF1R
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cancer, Developmental Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 215206(IGF1R Antibody) at a dilution of 1/30(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 215206(Anti-IGF1R Antibody) at dilution 1/30.
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