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IGHA1 Rabbit pAb

Anti-IGHA1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S218742

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S218742
Product Name:   Anti-IGHA1 Rabbit Polyclonal Antibody
Synonyms:   IgA1
UNIPROT ID:   P01876 (Gene Accession – BC005951 )
Background:    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Immunogen:    Fusion protein of human IGHA1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 218742(IGHA1 Antibody) at a dilution of 1/65(Secreted, Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 218742(Anti-IGHA1 Antibody) at dilution 1/65.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 218742(Anti-IGHA1 Antibody) at a dilution of 1/65.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with fusion protein and then with D225090(Anti-IGHA1 Antibody) at dilution 1/65.
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