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IL6ST Rabbit pAb

Anti-IL6ST Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S212157

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S212157
Product Name:   Anti-IL6ST Rabbit Polyclonal Antibody
Synonyms:   CD130; GP130; CDW130; IL-6RB
UNIPROT ID:   P40189 (Gene Accession – BC117402 )
Background:    The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
Immunogen:    Fusion protein of human IL6ST
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cancer, Cardiovascular, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer tissue using 212157(IL6ST Antibody) at a dilution of 1/40(Cell membrane).
          Publications