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KDM7A Rabbit pAb

Anti-KDM7A Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S222259

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S222259
Product Name:   Anti-KDM7A Rabbit Polyclonal Antibody
Synonyms:   JHDM1D
UNIPROT ID:   Q6ZMT4 (Gene Accession – NP_085150 )
Background:    Histone demethylase required for brain development. Specifically demethylates dimethylated ‘Lys-9’ and ‘Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ‘Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ‘Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Immunogen:    Synthetic peptide of human KDM7A
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 222259(KDM7A Antibody) at a dilution of 1/35(Cytoplasm and Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 222259(Anti-KDM7A Antibody) at dilution 1/35.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 222259(Anti-KDM7A Antibody) at a dilution of 1/35.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D264292(Anti-KDM7A Antibody) at dilution 1/35.
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