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KIF1C Rabbit pAb

Anti-KIF1C Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217559

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217559
Product Name:   Anti-KIF1C Rabbit Polyclonal Antibody
Synonyms:   SAX2; LTXS1; SATX2; SPAX2; SPG58
UNIPROT ID:   O43896 (Gene Accession – BC034993 )
Background:    The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell . Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis . KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons . Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle . Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta . In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
Immunogen:    Fusion protein of human KIF1C
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 200-1000;ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 217559(KIF1C Antibody) at a dilution of 1/60(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the fusion protein and then with 217559(Anti-KIF1C Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human sarcoma tissue using 217559(Anti-KIF1C Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human sarcoma tissue is first treated with fusion protein and then with D222582(Anti-KIF1C Antibody) at dilution 1/60.

Gel: 6%SDS-PAGE, Lysate: 40 μg;
Lane: A549 cells;
Primary antibody: 217559(KIF1C Antibody) at dilution 1/200;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 20 seconds
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