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KLK7 Rabbit pAb

Anti-KLK7 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216607

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216607
Product Name:   Anti-KLK7 Rabbit Polyclonal Antibody
Synonyms:   hK7, SCCE, PRSS6
UNIPROT ID:   P49862 (Gene Accession – BC032005 )
Background:    This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
Immunogen:    Fusion protein of human KLK7
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 25-100;WB: 500-2000;ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 216607(KLK7 Antibody) at a dilution of 1/10(Cytoplasm, Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the fusion protein and then with 216607(Anti-KLK7 Antibody) at dilution 1/10.

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 216607(Anti-KLK7 Antibody) at a dilution of 1/10.

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with fusion protein and then with D220906(Anti-KLK7 Antibody) at dilution 1/10.

Gel: 12%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: Mouse brain tissue, Mouse kidney tissue;
Primary antibody: 216607(KLK7 Antibody) at dilution 1/600;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 20 seconds
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