Email: info@neweastbio.com   |  Call: 6109452007

KLRK1 Rabbit pAb

Anti-KLRK1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221479

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221479
Product Name:   Anti-KLRK1 Rabbit Polyclonal Antibody
Synonyms:   KLR; CD314; NKG2D; NKG2-D; D12S2489E
UNIPROT ID:   P26718 (Gene Accession – NP_031386 )
Background:    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK comple,x a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Immunogen:    Synthetic peptide of human KLRK1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: Oct-50; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 221479(KLRK1 Antibody) at a dilution of 1/25(Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the synthetic peptide and then with 221479(Anti-KLRK1 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 221479(Anti-KLRK1 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D263091(Anti-KLRK1 Antibody) at dilution 1/25.
          Publications