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Ku70 (6H10) Mouse mAb

Anti-Ku70 (6H10) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261438

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261438
Product Name:   Anti-Ku70 (6H10) Mouse Monoclonal Antibody
Synonyms:   XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
UNIPROT ID:   P12956
Background:    It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.
Immunogen:    Purified recombinant human Ku70 protein fragments expressed in E.coli.
Applications:    WB,ICC/IF
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    6H10-E9-G7
MW:    Calculated MW: 70 kDa; Observed MW: 70 kDa
Isotype:    IgG2b
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing
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