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Ku70 (7B1) Mouse mAb

Anti-Ku70 (7B1) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261121

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261121
Product Name:   Anti-Ku70 (7B1) Mouse Monoclonal Antibody
Synonyms:   XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
UNIPROT ID:   P12956
Background:    It works in the 3′-5′ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.
Immunogen:    Purified recombinant human Ku70 protein fragments expressed in E.coli.
Applications:    WB,ICC/IF,IP,ChIP
Recommended Dilutions:    WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 ChIP: 1/20
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    7B1-E12-G4
MW:    Calculated MW: 70 kDa; Observed MW: 67 kDa
Isotype:    IgG1
Purification:    Affinity Purified
Species Reactivity:    Human,Monkey
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of Ku70 (7B1) in HeLa using Ku70 antibody.

Western blot analysis of Ku70 in Hela, A549, COS7 and K562 lysates using Ku70 antibody.

Immunoprecipitation analysis of Ku70 (7B1) in Hela lysates using Ku7 antibody.
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