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Lamin A/C Rabbit mAb

Anti-Lamin A/C Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262455

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262455
Product Name:   Anti-Lamin A/C Rabbit Monoclonal Antibody
Synonyms:   LMNA; LMN1; Prelamin-A/C
UNIPROT ID:   P02545
Background:    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Immunogen:    A synthetic peptide of human Lamin A/C
Applications:    WB,IHC-F,IHC-P,ICC/IF,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R06-7H5
MW:    Calculated MW: 74 kDa; Observed MW: 74,63 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    apoptosis – Caspase family
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of Lamin A/C(green) in Hela using Lamin A/C antibody,and DAPI(blue)

Western blot analysis of Lamin A/C in rat heart, rat skeletal muscle lysates using Lamin A/C antibody.

Western blot analysis of Lamin A/C in 3T3, Hela lysates using Lamin A/C antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
          Publications