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LATS1 Rabbit pAb

Anti-LATS1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S210873

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S210873
Product Name:   Anti-LATS1 Rabbit Polyclonal Antibody
Synonyms:   wts; WARTS
UNIPROT ID:   O95835 (Gene Accession – BC015665 )
Background:    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Immunogen:    Fusion protein of human LATS1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 210873(LATS1 Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the fusion protein and then with 210873(Anti-LATS1 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 210873(Anti-LATS1 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with fusion protein and then with D121797(Anti-LATS1 Antibody) at dilution 1/25.
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