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LSM11 Rabbit pAb

Anti-LSM11 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S211843

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S211843
Product Name:   Anti-LSM11 Rabbit Polyclonal Antibody
Synonyms:   
UNIPROT ID:   P83369 (Gene Accession – BC126449 )
Background:    Sm and Sm-like (LSm) proteins form donut-shaped, ubiquitously expressed heptameric complexes that are involved in various steps of RNA metabolism, including RNA-protein interactions and structural changes that are required during ribosomal subunit assembly. LSm11 is a 360 amino acid protein that localizes to the nucleus and belongs to the LSm subfamily of snRNP Sm proteins. Containing an N-terminal domain that is necessary for pre-mRNA cleavage, LSm11 functions to binds specifically to U7 snRNA and is thought to play a role in cell cycle regulation and cell growth. The gene encoding LSm11 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Immunogen:    Fusion protein of human LSM11
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human tonsil tissue using 211843(LSM11 Antibody) at a dilution of 1/20(Nucleus and Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with the fusion protein and then with 211843(Anti-LSM11 Antibody) at dilution 1/20.

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 211843(Anti-LSM11 Antibody) at a dilution of 1/20.

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with fusion protein and then with D123704(Anti-LSM11 Antibody) at dilution 1/20.
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