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MAGEB5 Rabbit pAb

Anti-MAGEB5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221463

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221463
Product Name:   Anti-MAGEB5 Rabbit Polyclonal Antibody
Synonyms:   CT3.3; MAGE-B5
UNIPROT ID:   Q9BZ81 (Gene Accession – NP_001258681 )
Background:    The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-B5 (melanoma-associated antigen B5), also known as CT3.3 (cancer/testis antigen 3.3), is a 275 amino acid protein that contains one MAGE domain and is expressed in testis. The gene encoding MAGE-B5 maps to human chromosome ,x which consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently, as males carry a single X chromosome.
Immunogen:    Synthetic peptide of human MAGEB5
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 20-100; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 221463(MAGEB5 Antibody) at a dilution of 1/20(Cytoplasm and Cell membrane).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 221463(Anti-MAGEB5 Antibody) at dilution 1/20.

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 221463(Anti-MAGEB5 Antibody) at a dilution of 1/20.

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with synthetic peptide and then with D263064(Anti-MAGEB5 Antibody) at dilution 1/20.
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