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MAP2K6 (8A11) Mouse mAb

Anti-MAP2K6 (8A11) Mouse Monoclonal Antibody
5/5

$349.00

Cat.#:  N261158

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N261158
Product Name:   Anti-MAP2K6 (8A11) Mouse Monoclonal Antibody
Synonyms:   MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3
UNIPROT ID:   P52564
Background:    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
Immunogen:    Purified recombinant human MKK6 protein fragments expressed in E.coli.
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Mouse
Clonality:    Mouse Monoclonal
Clone ID:    8A11-G11-G11
MW:    Calculated MW: 37 kDa; Observed MW: 40 kDa
Isotype:    IgG1
Purification:    Affinity Purified
Species Reactivity:    Human,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunoprecipitation analysis of MAP2K6 (8A11) in Hela lysates using MKK3/6 antibody.

Western blot analysis of MAP2K6 (8A11) in PC-12, C6, Ramos, Jurkat and Hela lysates using MKK3/6 antibody.
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