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MAPKAPK5 Rabbit pAb

Anti-MAPKAPK5 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217592

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217592
Product Name:   Anti-MAPKAPK5 Rabbit Polyclonal Antibody
Synonyms:   MK5; MK-5; PRAK; MAPKAP-K5
UNIPROT ID:   Q8IW41 (Gene Accession – BC041049 )
Background:    The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen:    Fusion protein of human MAPKAPK5
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 217592(MAPKAPK5 Antibody) at a dilution of 1/35(Nucleus and Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the fusion protein and then with 217592(Anti-MAPKAPK5 Antibody) at dilution 1/35.
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