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MCM10 Rabbit pAb

Anti-MCM10 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216637

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216637
Product Name:   Anti-MCM10 Rabbit Polyclonal Antibody
Synonyms:   CNA43; DNA43; PRO2249
UNIPROT ID:   Q7L590 (Gene Accession – BC009108 )
Background:    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Immunogen:    Fusion protein of human MCM10
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 30-150; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human brain tissue using 216637(MCM10 Antibody) at a dilution of 1/45(Cytoplasm and Nucleus).
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