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MEN1 Rabbit pAb

Anti-MEN1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221467

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221467
Product Name:   Anti-MEN1 Rabbit Polyclonal Antibody
Synonyms:   MEAI; SCG2
UNIPROT ID:   O00255 (Gene Accession – NP_000235 )
Background:    This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.
Immunogen:    Synthetic peptide of human MEN1
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 25-100;WB: 200-1000;ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 221467(MEN1 Antibody) at a dilution of 1/25(Nucleus or Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 221467(Anti-MEN1 Antibody) at dilution 1/25.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 221467(Anti-MEN1 Antibody) at a dilution of 1/25.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with synthetic peptide and then with D263072(Anti-MEN1 Antibody) at dilution 1/25.

Gel: 6%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: K562 and 293T cell lysates;
Primary antibody: 221467(MEN1 Antibody) at dilution 1/200;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 10 seconds
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