Email: info@neweastbio.com   |  Call: 6109452007

MICA Rabbit pAb

Anti-MICA Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216647

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216647
Product Name:   Anti-MICA Rabbit Polyclonal Antibody
Synonyms:   MIC-A; PERB11.1
UNIPROT ID:   Q29983 (Gene Accession – BC016929 )
Background:    This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Immunogen:    Fusion protein of human MICA
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 100-200;WB: 500-2000;ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 216647(MICA Antibody) at a dilution of 1/110(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the fusion protein and then with 216647(Anti-MICA Antibody) at dilution 1/110.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane 1-2: Human placenta tissue, Hela cell lysates;
Primary antibody: 216647(MICA Antibody) at dilution 1/700;
Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution;
Exposure time: 15 seconds
          Publications