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MLANA Rabbit pAb

Anti-MLANA Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S221466

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S221466
Product Name:   Anti-MLANA Rabbit Polyclonal Antibody
Synonyms:   MART1; MART-1
UNIPROT ID:   Q16655 (Gene Accession – NP_005502 )
Background:    Melan-A (also designated MART-1) is a melanocyte differentiation antigen that is specific to melanomas, melanocyte cell lines and retina. Melan-A peptide is recognized by most HLA-A2-restricted tumor-specific tumor-infiltrating lymphocytes in patients with melanoma. Antimelanoma cytotoxic T lymphocytes can be generated with a Melan-A peptide, implicating Melan-A as a potential candidate for antigen-specific immunotherapy in melanoma patients. Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Immunogen:    Synthetic peptide of human MLANA
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 40-250; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 221466(MLANA Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 221466(Anti-MLANA Antibody) at dilution 1/50.
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