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MLH1 Rabbit pAb

Anti-MLH1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216658

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216658
Product Name:   Anti-MLH1 Rabbit Polyclonal Antibody
Synonyms:   FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; LYNCH2; MMRCS1
UNIPROT ID:   P40692 (Gene Accession – BC006850 )
Background:    The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Immunogen:    Fusion protein of human MLH1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cancer
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 216658(MLH1 Antibody) at a dilution of 1/85(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 216658(Anti-MLH1 Antibody) at dilution 1/85.
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