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MLKL Rabbit pAb

Anti-MLKL Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219038

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219038
Product Name:   Anti-MLKL Rabbit Polyclonal Antibody
Synonyms:   hMLKL
UNIPROT ID:   Q8NB16 (Gene Accession – BC028141 )
Background:    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Immunogen:    Fusion protein of human MLKL
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-300; ELISA: 5000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 219038(MLKL Antibody) at a dilution of 1/85(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 219038(Anti-MLKL Antibody) at dilution 1/85.

The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using 219038(Anti-MLKL Antibody) at a dilution of 1/85.

In comparision with the IHC on the left, the same paraffin-embedded Human tonsil tissue is first treated with fusion protein and then with D225694(Anti-MLKL Antibody) at dilution 1/85.
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