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MMP11 Rabbit pAb

Anti-MMP11 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219922

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219922
Product Name:   Anti-MMP11 Rabbit Polyclonal Antibody
Synonyms:   ST3, SL-3, STMY3
UNIPROT ID:   P24347 (Gene Accession – AAH57788 )
Background:    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP’s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Immunogen:    Synthetic peptide of human MMP11
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 50-200;WB: 500-2000;ELISA: 1000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cardiovascular, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 219922(MMP11 Antibody) at a dilution of 1/40(Cytoplasm, ExtraCellular matrix).

In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 219922(Anti-MMP11 Antibody) at dilution 1/40.

The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using 219922(Anti-MMP11 Antibody) at a dilution of 1/40.

In comparision with the IHC on the left, the same paraffin-embedded Human renal cancer tissue is first treated with synthetic peptide and then with D260628(Anti-MMP11 Antibody) at dilution 1/40.

Gel: 10%SDS-PAGE, Lysate: 60 μg;
Lane 1-2: Human colon tissue, Human ovarian cancer tissue;
Primary antibody: 219922(MMP11 Antibody) at dilution 1/600;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 1 minute
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