Email: info@neweastbio.com   |  Call: 6109452007

MMP8 Rabbit pAb

Anti-MMP8 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S219918

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S219918
Product Name:   Anti-MMP8 Rabbit Polyclonal Antibody
Synonyms:   HNC, CLG1, MMP-8, PMNL-CL
UNIPROT ID:   P22894 (Gene Accession – NP_002415 )
Background:    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Immunogen:    Synthetic peptide of human MMP8
Applications:    ELISA, WB, IHC
Recommended Dilutions:    IHC: 25-100;WB: 500-2000;ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cancer, Cell Biology, Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 219918(MMP8 Antibody) at a dilution of 1/45(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 219918(Anti-MMP8 Antibody) at dilution 1/45.

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 219918(Anti-MMP8 Antibody) at a dilution of 1/45.

In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D260624(Anti-MMP8 Antibody) at dilution 1/45.

Gel: 8%SDS-PAGE, Lysate: 40 μg;
Lane: 231 cells;
Primary antibody: 219918(MMP8 Antibody) at dilution 1/800;
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution;
Exposure time: 10 seconds
          Publications