NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N226079 | ||||||
Product Name: Anti-MonoMethyl-Histone H3 (Lys4) Rabbit pAb | ||||||
Synonyms: H3K4me; H3 histone; HIST1H3A; Histone cluster 1; H3a | ||||||
UNIPROT ID: Q16695 | ||||||
Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. | ||||||
Immunogen: A synthetic methylated peptide corresponding to residues surrounding K4 of human histone H3 | ||||||
Applications: WB,IHC-F,IHC-P,ICC/IF | ||||||
Recommended Dilutions: WB: 1/500-1/1000 | ||||||
Host Species: Rabbit | ||||||
Clonality: Rabbit Polyclonal | ||||||
Clone ID: – | ||||||
MW: Calculated MW: 16 kDa; Observed MW: 16 kDa | ||||||
Isotype: IgG | ||||||
Purification: Affinity Purified | ||||||
Species Reactivity: Human,Mouse,Rat | ||||||
Conjugation: Unconjugated | ||||||
Modification: Methylated | ||||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||||
Research Areas: Epigenetics and Nuclear Signaling | ||||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||||
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