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MRE11 Rabbit pAb

Anti-MRE11 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217610

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217610
Product Name:   Anti-MRE11 Rabbit Polyclonal Antibody
Synonyms:   ATLD; HNGS1; MRE11A; MRE11B
UNIPROT ID:   P49959 (Gene Accession – NP_005582 )
Background:    This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3′ to 5′ exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3′ to 5′ exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Immunogen:    Fusion protein of human MRE11
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 100-300; ELISA: 2000-10000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 217610(MRE11 Antibody) at a dilution of 1/60(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 217610(Anti-MRE11 Antibody) at dilution 1/60.

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 217610(Anti-MRE11 Antibody) at a dilution of 1/60.

In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with fusion protein and then with D222698(Anti-MRE11 Antibody) at dilution 1/60.
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