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NEDD4L Rabbit pAb

Anti-NEDD4L Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217646

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217646
Product Name:   Anti-NEDD4L Rabbit Polyclonal Antibody
Synonyms:   RSP5; NEDD4-2; NEDD4.2; hNEDD4-2
UNIPROT ID:   Q96PU5 (Gene Accession – BC032597 )
Background:    This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.
Immunogen:    Fusion protein of human NEDD4L
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 50-200; ELISA: 2000-5000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human prostate cancer tissue using 217646(NEDD4L Antibody) at a dilution of 1/50(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with the fusion protein and then with 217646(Anti-NEDD4L Antibody) at dilution 1/50.
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