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NR0B2 Rabbit pAb

Anti-NR0B2 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S216774

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S216774
Product Name:   Anti-NR0B2 Rabbit Polyclonal Antibody
Synonyms:   SHP; SHP1
UNIPROT ID:   Q15466 (Gene Accession – BC030207 )
Background:    The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Immunogen:    Fusion protein of human NR0B2
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Metabolism, Signal Transduction, Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human liver cancer tissue using 216774(NR0B2 Antibody) at a dilution of 1/30(Cytoplasm).

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer tissue using 216774(Anti-NR0B2 Antibody) at a dilution of 1/30.
          Publications