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NUMB Rabbit mAb

Anti-NUMB Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262635

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262635
Product Name:   Anti-NUMB Rabbit Monoclonal Antibody
Synonyms:   NUMB; Protein numb homolog; h-Numb; Protein S171
UNIPROT ID:   P49757
Background:    Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.
Immunogen:    Recombinant protein of human NUMB
Applications:    WB,IHC-P,IP
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R09-2I5
MW:    Calculated MW: 71 kDa; Observed MW: 71 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using NUMB antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of NUMB in 3T3, C6, rat Brain, MCF-7 lysates using NUMB antibody.
          Publications