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OPTN Rabbit pAb

Anti-OPTN Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  S217718

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   S217718
Product Name:   Anti-OPTN Rabbit Polyclonal Antibody
Synonyms:   NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
UNIPROT ID:   Q96CV9 (Gene Accession – BC013876 )
Background:    This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.
Immunogen:    Fusion protein of human OPTN
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human, Mouse, Rat
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Neuroscience, Immunology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 217718(OPTN Antibody) at a dilution of 1/25(Cytoplasm).

In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 217718(Anti-OPTN Antibody) at dilution 1/25.
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