NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: S220784 | ||||
Product Name: Anti-PBOV1 Rabbit Polyclonal Antibody | ||||
Synonyms: UC28; UROC28; dJ171N11.2 | ||||
UNIPROT ID: Q9GZY1 (Gene Accession – NP_067648 ) | ||||
Background: UROC28, also known as PBOV1 (prostate and breast cancer overexpressed 1) or UC28, is a 135 amino acid cytoplasmic and nuclear protein that is expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary and peripheral blood leukocytes. UROC28 is up-regulated in prostate, breast and bladder cancer, and is thereby considered a useful target for diagnosis and treatment of these cancers. UROC28 is encoded by a gene located on human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. | ||||
Immunogen: Synthetic peptide of human PBOV1 | ||||
Applications: ELISA, WB, IHC | ||||
Recommended Dilutions: IHC: Oct-50;WB: 200-1000;ELISA: 5000-10000 | ||||
Host Species: Rabbit | ||||
Clonality: Rabbit Polyclonal | ||||
Isotype: Immunogen-specific rabbit IgG | ||||
Purification: Antigen affinity purification | ||||
Species Reactivity: Human | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||||
Research Areas: Epigenetics and Nuclear Signaling, Cancer | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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