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Pellino 1 Rabbit mAb

Anti-Pellino 1 Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N262694

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N262694
Product Name:   Anti-Pellino 1 Rabbit Monoclonal Antibody
Synonyms:   Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1
UNIPROT ID:   Q96FA3
Background:    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates ‘Lys-63’-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates ‘Lys-48’-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the ‘Thr-182’ phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates ‘Lys-63’-linked ubiquitination of RIPK1 (PubMed:29883609).
Immunogen:    Recombinant protein of human Pellino 1
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R07-0E3
MW:    Calculated MW: 46 kDa; Observed MW: 46 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Pellino 1 in rat Brain, Jurkat lysates using Pellino 1 antibody.
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