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PHD1 Rabbit pAb

Anti-PHD1 Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225560

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225560
Product Name:   Anti-PHD1 Rabbit pAb
Synonyms:   Estrogen-induced tag 6; HPH-3; PHD1
UNIPROT ID:   Q96KS0
Background:    Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Immunogen:    A synthesized peptide derived from human PHD1/prolyl hydroxylase
Applications:    WB,IHC-P,ICC/IF,FC
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 44 kDa; Observed MW: 44 kDa
Isotype:    IgG
Purification:    Affinity Chromatography
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Cardiovascular
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of PHD1 in (1) HeLa lysates; (2) A549 lysates using PHD1 antibody.
          Publications