NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N263150 | ||
Product Name: Anti-Phospho-Amyloid Precursor Protein (Thr743) Rabbit Monoclonal Antibody | ||
Synonyms: APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II | ||
UNIPROT ID: P05067 | ||
Background: APP a cell surface receptor that influences neurite growth, neuronal adhesion and axonogenesis. Cleaved by secretases to form a number of peptides, some of which bind to the acetyltransferase complex Fe65/TIP60 to promote transcriptional activation. | ||
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein | ||
Applications: WB,ICC/IF,IP | ||
Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 | ||
Host Species: Rabbit | ||
Clonality: Rabbit Monoclonal | ||
Clone ID: R07-4D0 | ||
MW: Calculated MW: 87 kDa; Observed MW: 100 kDa | ||
Isotype: IgG | ||
Purification: Affinity Purified | ||
Species Reactivity: Human,Rat | ||
Conjugation: Unconjugated | ||
Modification: Phosphorylated | ||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||
Research Areas: NeuroscienceyyyyyAlzheimer’s disease | ||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||
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