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Phospho-Chk2 (Thr68) Rabbit pAb

Anti-Phospho-Chk2 (Thr68) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225381

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225381
Product Name:   Anti-Phospho-Chk2 (Thr68) Rabbit pAb
Synonyms:   CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2
UNIPROT ID:   O96017
Background:    These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
Immunogen:    The antiserum was produced against synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68. AA range:35-84
Applications:    WB,ICC/IF,IHC-P
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 61 kDa; Observed MW: 61 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse,Rat
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-Chk2(Thr68) in Jurkat treated with UV lysates using Phospho- Chk2 (Thr68) antibody.
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