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Phospho-HDAC5 (Ser498) Rabbit pAb

Anti-Phospho-HDAC5 (Ser498) Rabbit Polyclonal Antibody
5/5

$349.00

Cat.#:  N225298

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N225298
Product Name:   Anti-Phospho-HDAC5 (Ser498) Rabbit pAb
Synonyms:   HD5; NY-CO-9
UNIPROT ID:   Q9UQL6
Background:    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Immunogen:    Synthetic peptide of human HDAC5
Applications:    WB,IHC-P
Recommended Dilutions:    WB: 1/500-1/1000 IHC: 1/50-1/100
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Clone ID:   
MW:    Calculated MW: 122 kDa; Observed MW: 122 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human,Mouse
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using HDAC5(Phospho-Ser498) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.

Western blot analysis of Phospho-HDAC5 (Ser498) in 293 lysates using Phospho-HDAC5 (Ser498) antibody.
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