NewEast Biosciences pioneered the research and development of the antibodies for GTPases and mutated Oncogene ten years ago. GTPases involve (1) signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision, (2) protein biosynthesis at the ribosome, (3) regulation of cell differentiation, proliferation, division and movement, (4) translocation of proteins through membranes, (5) transport of vesicles within the cell, and vesicle-mediated secretion and uptake, through GTPase control of vesicle coat assembly. An oncogene is a gene that has the potential to cause cancer.
We offer three unique categories of antibodies, which (1) recognize only the active configuration of GTPase (not the inactive one), (2) mutated Oncogene (not mild type) and (3) have super affinity for cAMP and cGMP (no acetylation required). We have over one thousand peer reviewed articles cited our products.
$349.00
Cat.#: N261450 | ||||
Product Name: Anti-Phospho-Histone H2A.X (Ser139) (2A9) Mouse Monoclonal Antibody | ||||
Synonyms: H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X; gamma H2A.X | ||||
UNIPROT ID: P16104 | ||||
Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. | ||||
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Ser139 of human H2A.X. | ||||
Applications: WB,ICC/IF | ||||
Recommended Dilutions: WB: 1/500-1/1000 IF: 1/50-1/200 | ||||
Host Species: Mouse | ||||
Clonality: Mouse Monoclonal | ||||
Clone ID: 2A9-B5 | ||||
MW: Calculated MW: 15 kDa; Observed MW: 15 kDa | ||||
Isotype: IgG2a | ||||
Purification: Affinity Purified | ||||
Species Reactivity: Human,Mouse | ||||
Conjugation: Unconjugated | ||||
Modification: Phosphorylated | ||||
Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
Research Areas: Epigenetics and Nuclear Signaling | ||||
Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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