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Phospho-IRE1 (Ser724) Rabbit mAb

Anti-Phospho-IRE1 (Ser724) Rabbit Monoclonal Antibody
5/5

$349.00

Cat.#:  N263172

   Size:   100 μl

In Stock

          Product Description          
Cat.#:   N263172
Product Name:   Anti-Phospho-IRE1 (Ser724) Rabbit Monoclonal Antibody
Synonyms:   ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
UNIPROT ID:   O75460
Background:    Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Immunogen:    A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R05-6E7
MW:    Calculated MW: 110 kDa; Observed MW: 110 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Human
Conjugation:    Unconjugated
Modification:    Phosphorylated
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Signal Transduction
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Phospho-IRE1 (Ser724) in MCF-7, HL-60 lysates using Phospho-IRE1 (Ser724) antibody.
          Publications